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InChi: InChI=1S/C11H16O2/c1-3-4-5-6-7-8-9-10-11(12)13-2/h5-10H
CAS Number: 1991986-30-1
Inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer
01% at concentrations of 50
0 mg/kg in mouse T-maze model
PF-6274484 - CAS# 1035638-91-5 Catalog No.:M17303-C InChi: InChI=1S/C11H16O2/c1-3-4-5-6-7-8-9-10-11(12)13-2/h5-10HPF 6274484 is a potent EGFR inhibitor with Kis of 0. 14 nM and 0. 18 nM for EGFR L858R T790M and WT EGFR, respectively. PF 6274484 inhibits EGFR L858R T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6. 6 and 5. 8 nM, respectively. Product information CAS Number: 1035638 91 5 Molecular Weight: 372. 78 Formula: C18H14ClFN4O2 Chemical Name: N {4 [(3 chloro 4 fluorophenyl)amino] 7 methoxyquinazolin 6 yl}prop 2
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