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There are 15 Autobots and Decepticons represented here, all appearing at Mythic rarity, so theres no reason to expect that Optimus Prime will be harder to get ahold of than say, Slicer (other than fan favoritism, of course)

Four life is a lot, especially when it is killing something small

Use Trap Cards to restrict the movements of your opponent, then once the times right, Xyz Summon Number 39: Utopia Double, then attack with Utopia to seize victory.

However, modern sets are still phenomenally expensive at times

Taking an artifact or creature card means it hurts the majority of cards in the set, so you shouldnt miss very often