Ruxolitinib sulfate - CAS# 1092939-16-6 alog 2 Smiles: C(NC1=NC2=CC=CC=C2C(NCC2C=CC=CC=2)=N1)C1C=CC=CC=1

Smiles: C(NC1=NC2=CC=CC=C2C(NCC2C=CC=CC=2)=N1)C1C=CC=CC=1

exposure of CLL cells to Tnv-6 did not induce cellular apoptosis or p53-pathway activity

ethyl ester

CAS Number: 1093978-89-2

InChiKey: JYGXADMDTFJGBT-VWUMJDOOSA-N

Ruxolitinib sulfate - CAS# 1092939-16-6 alog 2 Smiles: C(NC1=NC2=CC=CC=C2C(NCC2C=CC=CC=2)=N1)C1C=CC=CC=1Ruxolitinib sulfate is the first potent, selective JAK1 2 inhibitor to enter the clinic with IC50s of 3. 3 nM 2. 8 nM, and has > 130 fold selectivity for JAK1 2 versus JAK3. Ruxolitinib potently and selectively inhibits JAK2V617F mediated signaling and proliferation, markedly increases apoptosis in a dose dependent manner, and at 64 nM results in a doubling of cells with depolarized mitochondria in Ba F3 cells. Ruxolitinib demonstrates remarkable