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Unless you have some political reason to spend your card this way, you should probably hold your removal until the Serra Ascendant is pointed toward you

You also want to ensure that you can either protect your creatures in the event of a board wipe or rebuild as quickly as possible after one, and that's where a strong mana base comes into play

If you cant, sacrifice Egon and draw a card

Gale, Waterdeep Prodigy is an excellent way to double the value of instants and sorceries, so long as you are playing enough of both