Mana Drain is the most powerful hard counter ever printed without an alternative cost, and became strictly better than Counterspell once the mana burn was eliminated in the Magic 2010 rule changes
Ghastlord of Fugue is an unblockable creature that can get rid of problematic cards from opponents hands
Its a bit better than that, and it subtly gives some hate to the decks that revolve around interactions with tokens like Treasure tokens, or even Clue tokens
So yes, Etali, Primal Conqueror is an extremely good pay off in the command zone for decks that win with Food Chain, if you can keep casting a creature such as Squee, the Immortal from exile to generate 10 million mana or something
There are a number of styles out there that folks are playing, but away from the competitive Constructed tables, what is the best