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Ferrari RH
Smiles: O/N=C1\CCC2=CC(=CC=C2\1)C1=CN(CCO)N=C1C1C=CN=CC=1
AT13148 inhibits a panel of kinases at 10 μM
InChi: InChI=1S/C24H27ClN2O4/c1-28-20-7-4-17(12-22(20)29-2)10-11-26-14-18-5-8-21(23(13-18)30-3)31-16-19-6-9-24(25)27-15-19/h4-9
It can decrease viability and increase apoptosis of K-Ras(G12C)-containing cancer cell lines
Embelin 312 Ferrari RHApomorphine Hydrochloride, also known as APL 130277 and TAK 251, is a dopamine D2 agonist used for the treatment of Parkinson's disease. Apomorphine also promotes intraneuronal amyloid (A) degradation and improves memory function in an Alzheimer's disease model. Protein levels of two types of serine phosphorylated insulin receptor substrate 1 (IRS 1), pS616 and pS636 639, significantly decreased following Apomorphine treatment in the 13 month old 3xTg
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