Losartan Carboxaldehyde 6681509 ACY-957 is an orally active

ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2

4-triazin-3-one

an active metabolite of the prodrug Bromhexine

3-1(4)2(5)6/h8H

Solubility: DMSO : 100 mg/mL (554

Losartan Carboxaldehyde 6681509 ACY-957 is an orally activeLosartan is an inhibitor of endothelial cyclooxygenase (COX) 2. COX 2 produces prostaglandins that inhibit apoptosis and stimulate angiogenesis and invasiveness, and thus selective COX 2 inhibitors can reduce prostaglandin synthesis and restore apoptosis. In vitro: Losartan is an intermediate aldehyde metabolite of losartan, the angiotensin II type 1 receptor antagonist. Losartan could not block angiotensin receptors, but inhibit the expression of