Taccalonolide A 42112 CC1(C)C2CCC1(CS([O-])(=O)=O)C(=O)C2=CC1C=CC(C=C2C3CCC(CS([O-])(=O)=O)(C2=O)C3(C)C)=CC=1

CC1(C)C2CCC1(CS([O-])(=O)=O)C(=O)C2=CC1C=CC(C=C2C3CCC(CS([O-])(=O)=O)(C2=O)C3(C)C)=CC=1

Chemical Name: ethyl 6-{[(2S)-1-[(2S

including the United Kingdom

and leads to further increases in airways hyperresponsiveness

Formula: C30H32Cl3NO

Taccalonolide A 42112 CC1(C)C2CCC1(CS([O-])(=O)=O)C(=O)C2=CC1C=CC(C=C2C3CCC(CS([O-])(=O)=O)(C2=O)C3(C)C)=CC=1Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities. Taccalonolide A causes G2 M accumulation, Bcl 2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK OV 3 cells. Product information CAS Number: 108885 68