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InChi: InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5
in CHMCs (Cultured human mast cells)
Desogestrel-containing birth control pills are sometimes referred to as "third generation" oral contraceptives
PubMed Central PMCID: PMC3529962
3'-bipyrrole]-2-carbonyl]phenol
WP1066 Size:Solid 2 mg InChi: InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5WP1066 is a Stat3 inhibitor and JAK2 inhibitor. WP1066 is also a novel analogue of the JAK2 inhibitor AG490, in JAK2 V617F positive erythroleukemia HEL cells and in blood cells from patients with polycythemia vera. WP1066 significantly inhibited JAK2 and its downstream signal transducer and activator of transcription 3, signal transducer and activator of transcription 5, and extracellular signal regulated kinase 1 2 pathways in a dose and time
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