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Chemical Name: 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol hydrochloride
It blocks hyperpolarization-activated inward current (If) through cyclic nucleotide-gated cation (HCN) channels in sinoatrial node cells
modestly reduces in mean channel open time
It Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1
CAS Number: 2098836-54-3
MG-277 164015 Chemical Name: 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol hydrochlorideMG 277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1. 3 nM. MG 277 potently inhibits tumor cell growth in a p53 independent manner, with IC50s of 3. 5 nM for RS4; 11 cells and 3. 4 nM for p53 mutant RS4; 11 IRMI 2 cells, respectively. Anticancer activity. Product information CAS Number: 2411085 89 5 Molecular Weight: 774. 71 Formula: C41H42Cl2FN5O5 Chemical Name: (3'R,4'S,5'R)
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