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ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model
HI/c1-5-20-35(22-13-21-33(2)3)31-23-25(24-32-34(4)29-18-11-12-19-30(29)37-32)27-16-9-10-17-28(27)36(31)26-14-7-6-8-15-26
the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety
Yazzie-Atkinson D
Chemical Name: tert-butyl 9-{[2-(2
γ-Amanitin PBA) ML265: A potent PKM2 activatorAmanitin an ADC cytotoxin and isolated from the mushroom. Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. Amanitin shows similar effects to Amanitin and Amanitin. Product information CAS Number: 21150 23 2 Molecular Weight: 902. 97 Formula: C39H54N10O13S Chemical Name: 2 [(1R, 4S, 8R, 10S, 13S, 16S, 34S) 34 [(2S) butan 2 yl] 8, 22 dihydroxy 13 [(2R, 3S) 3 hydroxybutan 2 yl] 2, 5, 11, 14, 27, 30, 33, 36, 39 nonaoxo 27 thia 3, 6, 12,