Tebanicline hydrochloride Size:Contact [email protected] for quotation is a pyrrolidinone-type cognition enhancer

is a pyrrolidinone-type cognition enhancer that has been clinically used in the treatment of behavioral and psychological symptoms of dementia following stroke and in Alzheimer's disease

Rescriptor

at high potency with an IC50 of 25 nM

4-dimethoxyphenyl)ethyl]amino}-2-[(1

The low-affinity site accounts for the residual 75% of binding (IC50) 790 nM and represents binding to the R1a sites

Tebanicline hydrochloride Size:Contact [email protected] for quotation is a pyrrolidinone-type cognition enhancerTebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to 42 neuronal nAChRs with a Ki of 37 pM. Tebanicline is a novel, potent cholinergic nAChR ligand with analgesic properties that shows preferential selectivity for neuronal nAChRs. It inhibits the binding of cytisine to 42 neuronal nAChRs with a Ki of 37 pM. Functionally, tebanicline is an agonist.