AZD3759 - CAS# 1626387-80-1 Catalog No.:M6469-10 GSK343 was used at 10-50

GSK343 was used at 10-50 µM final concentration in vitro and in cellular assays

SGC website: http://www

PubMed Central PMCID: PMC3587237

6 logs after 48 hours from a single 100 mg) dosefollowing a single dose in patients chronically infected with HCV genotype 1

is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with an IC50 ~0

AZD3759 - CAS# 1626387-80-1 Catalog No.:M6469-10 GSK343 was used at 10-50AZD3759, CAS No. 1626387 80 1, is also known as zorifertinib. It is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR overexpressing cells. EGFR,