SC-10914 pferol 3-O-gentiobioside Smiles: CC(C)(C)OC(=O)N(CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

Smiles: CC(C)(C)OC(=O)N(CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

BIIE-0246 inhibits fat mass gain (P=0

CAS Number: 2029049-79-2

Formula: C19H19ClF2N4O

H2O : 5 mg/mL (15

SC-10914 pferol 3-O-gentiobioside Smiles: CC(C)(C)OC(=O)N(CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=OSC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7. 87 nM) with potent anti proliferative activity against human BRCA deficient tumor cells (MDA MB 436, BRCA1 deficient, IC50 = 4. 03 nM, Capan 1 BRCA2 deficient, IC50 = 11. 66 nM) and PTEN deficient tumor cells (HGC 27, PTEN deficient, IC50 = 0. 35 M). SC10914 showed potent anti tumor activity in BRCA1 2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as