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JUN76288 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ΌΝΑ repair before mitotic entry
Cilomilast reduces TLR4 expression
InChi: InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3
InChiKey: LJBQRRQTZUJWRC-UHFFFAOYSA-N
CH4O3S/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13
Fedratinib hydrochloride hydrate ((2S)-1 2-propanediol hydrate) JUN76288 kinase plays a roleFedratinib hydrochloride hydrate (TG 101348 hydrochloride hydrate) is a potent, selective, ATP competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35 and 334 fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research. Product information CAS Number: