(R)-5-Hydroxymethyl Tolterodine 2 inhibitor 1 11aR)-11-hydroxy-3a

11aR)-11-hydroxy-3a

which is probably responsible for many of its unique properties

TIMP2 and TIMP3 are regulators of cardiac remodeling

CAS Number: 208255-80-5

1009119-65-6

(R)-5-Hydroxymethyl Tolterodine 2 inhibitor 1 11aR)-11-hydroxy-3aDesfesoterodine, also known as PNU 200577, is a major pharmacologically active metabolite of tolterodine, a new muscarinic receptor antagonist intended for the treatment of an overactive bladder. In vitro, PNU 200577 produced a competitive and concentration dependent inhibition of carbachol induced contraction of guinea pig isolated urinary bladder strips (KB = 0. 84 nM; pA2 = 9. 14). In vivo, PNU 200577 was significantly more potent at inhibiting