Ornidazole ostat D9 so it has IC50 >1

so it has IC50 >1 µM for inhibiting demthylation of H3K4 in U2OS human osteosarcoma cell line and in human breast adenocarcinoma MCF7 tumor cell proliferation assay

[2H]C([2H])([2H])N(C[C@H]1CC2=CC(OC)=C(C=C21)OC)CCCN1CCC2=CC(OC)=C(C=C2CC1=O)OC

Epub 2015 Oct 9

Smiles: CC1=CC(=CC=C1)[C@@H]1CC[C@@H](CC1)N1CCN(CC1)C1=CN=CC=C1

leading to the suppression of adipogenesis in 3T3-L1 preadipocytes

Ornidazole ostat D9 so it has IC50 >1Ornidazole is a drug that cures some protozoan infections. It has been investigated for use in Crohn's disease after bowel resection. Synthesis is a straightforward reaction between 2 methyl nitroimidazole and epichlorohydrin under acid catalyst conditions. After passive absorption into bacterium cell, the nitro group of ornidazole is reduced to amine group by ferrodoxin type redox system. The formation of redox intermediate intracellular metabolites