SD-36 Catalog No.:M13867-2 6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1

6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1

Chemical Name: 4-{6-[6-(4-methylpiperazin-1-yl)-1H-1

An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM

Smiles: CC1=NC=C(N1CCO)N(=O)=O

CAS Number: 13422-55-4

SD-36 Catalog No.:M13867-2 6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1SD 36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD 36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD 36 exerts robust anti tumor activity, and achieves complete and long lasting tumor regression in mouse tumor models. SD 36 is composed of the STAT3 inhibitor SI 109, a linker, and an analog of