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14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic
220 nM (ULK2)
which was also consistent with predicted clearance using in vitro data from monkey liver microsomes
and KCNQ1) as well as no activity on GABA(A) gated channels at 10 μM
InChi: InChI=1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5
GLP-1R Antagonist 1 oxy-PEG2-alcohol 14-PGJ2 (15d-PGJ2) is a cyclopentenoneGLP 1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non competitive antagonist of glucagon like peptide 1 receptor (GLP 1R), with an IC50 of 650 nM. Product information CAS Number: 488097 06 9 Molecular Weight: 440. 73 Formula: C16H11ClF6N4O2 Chemical Name: 7 (4 chlorophenyl) 1,3 dimethyl 5,5 bis(trifluoromethyl) 1H,2H,3H,4H,5H,8H [1,3]diazino[4,5 d]pyrimidine 2,4 dione Smiles:
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