WEHI-539 HCl Size:10mg solid MG132 also inhibits NF-κB activation

MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage

BMS-3 inhibits A549 human lung cancer cells with EC50 value of 154 nM[1]

Formula: C21H20O10

Epub 2014 Mar 1

Bortezomib treatment leads to PARP cleavage in a time-dependent manner with concentrations as low as 100 nM being effective at 24 hr

WEHI-539 HCl Size:10mg solid MG132 also inhibits NF-κB activationWEHI 539 HCl (WEHI 539 hydrochloride) has high affinity (IC50=1. 1 nM) and selectivity for BCL XL and potently kills cells by selectively antagonizing its prosurvival activity. It has more than a 400 fold higher affinity for BCL XL versus other prosurvival BCL 2 family members. Product information CAS Number: 2070018 33 4 Molecular Weight: 620. 18 Formula: C31H30ClN5O3S2 Synonym: WEHI 539 hydrochloride Chemical Name: 4 Thiazolecarboxylic acid, 5 [3 [4