![(S)-Willardiine Catalog No.:M8448-2 Smiles: CC1C[C@@]2(N)/C(=C\C)/[C@H](CC3NC(=O)C=CC2=3)C=1](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M8448_1621503613.gif?v=1626226189)
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Smiles: CC1C[C@@]2(N)/C(=C\C)/[C@H](CC3NC(=O)C=CC2=3)C=1
37 and 97% TGI
Formula: C24H26N6O3
pharmthera
[2] KD025 ()150 mg/kg
(S)-Willardiine Catalog No.:M8448-2 Smiles: CC1C[C@@]2(N)/C(=C\C)/[C@H](CC3NC(=O)C=CC2=3)C=1(S) Willardiine is a potent agonist of AMPA kainate receptors with EC50 of 44. 8 uM. IC50 value: 44. 8 uM(EC50) Target: AMPA kainate receptor agonistin vitro: The (S) but not (R) isomers of willardiine and 5 bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses . At a concentration of 1. 8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% . in vivo: In newborn mice (P5,
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