MGCD0103 - CAS# 726169-73-9 Catalog No.:M6555-10 32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24

32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24

When Delpazolid (LCB-0371) is administered at 100 mg/kg daily (by gavage)

Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen

Pilling PA

and potential for combination in preclinical models

MGCD0103 - CAS# 726169-73-9 Catalog No.:M6555-10 32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24MGCD0103, also known as Mocetinostat, CAS No. 726169 73 9, is a rationally designed, orally available, Class 1 selective, small molecule, 2 aminobenzamide HDAC inhibitor with potential antineoplastic activity. MGCD0103 binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur