ARL 17477 dihydrochloride B2 Ligand Smiles: CC1C=C(C(=CC=1C(=O)NC(N)=N)S(C)(=O)=O)N1C=CC=C1

Smiles: CC1C=C(C(=CC=1C(=O)NC(N)=N)S(C)(=O)=O)N1C=CC=C1

van Bochove GG

PubMed PMID: 23865465

Formula: C24H25Cl2N5O3

Formula: C29H37Cl3N6O

ARL 17477 dihydrochloride B2 Ligand Smiles: CC1C=C(C(=CC=1C(=O)NC(N)=N)S(C)(=O)=O)N1C=CC=C1ARL 17477 dihydrochloride is a selective and potent neuronal nitrogen oxide synthase (nNOS) inhibitor with IC50 values of 1 and 17M for nNOS and endothelial NOS, respectively . Neuronal NOS (nNOS) plays an important role in the development of ischaemic brain necrosis while endothelial NOS (eNOS) protects brain tissue through increasing ischaemic regional cerebral blood flow . In rats after transient MCA occlusion, ARL 17477 (1mg kg, 3mg kg and 10mg