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is a ubiquitin-activating enzyme inhibitor (UBE1 inhibitor)
6 112 PMID: 28553460
Smiles: CC(C)C(=O)NC1=NC=C(S1)C1=CC(=NN1C1=C(Cl)C=CC=C1Cl)C(F)F
BX471 (20 mg/kg
antioxidant
ML277 - CAS# 1401242-74-7 etarrestin (ML246) is a ubiquitin-activating enzyme inhibitorML277, CAS No. 1401242 74 7, is a potent activator of KCNQ1 (Kv7. 1) channels with >100 fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 M. KCNQ1 is a voltage gated potassium channel required for repolarization phase of the cardiac action potential. ML277 is the first selective and potent activator found, with an EC50 of 260 nM. Product information CAS Number: 1401242 74 7 Molecular Weight: 471. 59
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