Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
(2002) J Neuropathol Exp Neurol
Formula: C27H30ClFN4O3
rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system
2, 4-Pyridinedicarboxylic Acid 879OE-S 785026 trihydrochloride Kahweol (20-40 μM) significantly decreased2,4 Pyridinedicarboxylic Acid (2,4 PDCA) is an inhibitor of histone lysine specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1. 4 M), KDM5B (IC50, 3 M), KDM6A and other 2 oxogynases . Histone lysine specific demethylases JMJD2A (KDM4A) and KDM4C are both members of the Jumonji domain 2 (JMJD2) family and function as trimethylation specific demethylases, converting specific trimethylated histone residues to the dimethylated