Polygalasaponin XXXI ycholanoic acid OSI-027 shows robust antitumor activity

OSI-027 shows robust antitumor activity in several different human xenograft models representing various histologies

17-31)20(27)10-13-30(21

but not in HEK293 cells expressing cannabinoid receptor 1 or 2 (CB1 or CB2)

Defactinib

CI-1044 selectively inhibits PDE4 crude extract from U937 cells with an IC50 value of 0

Polygalasaponin XXXI ycholanoic acid OSI-027 shows robust antitumor activityPolygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection. Product information CAS Number: 79103 90 5 Molecular Weight: 1589. 67 Formula: C75H112O36 Chemical Name: (2S,3R,4S,4aR,6aR,6bR,8aS,12aS,14aR,14bR) 8a ({[(2S,3R,4S,5R,6R) 3 {[(2S,3R,4S,5S,6S) 4 {[(2S,3R,4R) 3,4 dihydroxy 4 (hydroxymethyl)oxolan 2 yl]oxy} 5 {[(2S,3R,4S,5R) 3,5