PF-5274857 773 Smiles: C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=C(F)C(=O)NC1=O

Smiles: C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=C(F)C(=O)NC1=O

5-3(6)1-2-4(7)8/h6-9

and DNA-PK

Reserpine hydrochloride at doses of 0

8-fold increase in GPR120 mRNA expression

PF-5274857 773 Smiles: C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=C(F)C(=O)NC1=OPF 5274857 is a potent, orally active and selective hedgehog (Hh) signaling pathway inhibitor with an IC50 of 5. 8 nM and a Ki of 4. 6 nM. PF 5274857 was found to effectively penetrate the blood brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF 5274857 was orally available and metabolically stable in vivo. PF 5274857 is a potentially attractive clinical candidate for