2-Hydroxyestradiol Size:Contact [email protected] for quotation InChi: InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8

InChi: InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8

25)15(9)22/h6-7

Fangqing Zhang

BAY-876 (25-75 nM

Solubility: DMSO: 71 mg/mL(198

2-Hydroxyestradiol Size:Contact [email protected] for quotation InChi: InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(82 Hydroxyestradiol is an angiogenesis inhibitor via the HIF 1a pathway. HIF 1a, a basic helix loop helix PAS domain containing protein, is reported as the master transcriptional regulator of cellular and developmental response to hypoxia. In vitro: In vitro evidences suggested that most of the cellular effects of 2 hydroxyestradiol were mediated by 2 methoxyestradiol, a metabolite of 2 hydroxyestradiol as an anti cancer agent acting as an angiogenesis