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4 mM PD0325901 and 1 mM CHIR99021 in DMSO
It demonstrates >100-fold selectivity for PKM2 over the related PKM1
Ixazomib: an investigational drug for the treatment of lymphoproliferative disorders
Molecular Weight: 497
von Loga I
Daporinad - CAS# 658084-64-1 Catalog No.:M6580-10 4 mM PD0325901 and 1Daporinad, also known as APO 866 and FK866, CAS No. 658084 64 1, is a small molecule with potential antineoplastic and antiangiogenic activities. NMPRTase inhibitor APO866 binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In