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with IC50 of 26±3 nM (n=21)
GSK-J4 could be a unique small molecule to allow selective pharmacological intervention across the JMJ family
5% is the 13-cis and less than 1% is the 9-cis with 94% being all-trans
Chemical Name: 1-(4-(4-(8-oxa-3-azabicyclo[3
ClH/c1-43(2)36-12-8-10-14-38(36)48(20-24-54-28-32-57-31-27-53-23-19-46-47-45)40(43)16-6-5-7-17-41-44(3
RAS inhibitor Abd-7 Size:Contact [email protected] for quotation with IC50 of 26±3 nMRAS inhibitor Abd 7, a potent RAS binding compound (Kd=51 nM), is a RAS effector protein protein interaction (PPI) inhibitor. RAS inhibitor Abd 7 interacts with RAS inside the cells, prevents RAS effector interactions and inhibits endogenous RAS dependent signaling. RAS inhibitor Abd 7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V. Product information CAS Number: 2351843 48 4 Molecular
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