ABC294640 - CAS# 915385-81-8 Catalog No.:M6465-10 Smiles: C[C@@H]1COCCN1C1=CC(=NC(=N1)C1C=CC=C2NC=CC=12)C1(CC1)S(C)(=O)=O

Smiles: C[C@@H]1COCCN1C1=CC(=NC(=N1)C1C=CC=C2NC=CC=12)C1(CC1)S(C)(=O)=O

Formula: C12H15N3O2

PKC-iota inhibitor 1

CPI203 could be dosed to the mice by oral administration at 5 mg/kg twice per day for 7 days

and peak plasma concentration was 58 μM

ABC294640 - CAS# 915385-81-8 Catalog No.:M6465-10 Smiles: C[C@@H]1COCCN1C1=CC(=NC(=N1)C1C=CC=C2NC=CC=12)C1(CC1)S(C)(=O)=OABC294640, also known as Opaganib, CAS No. 915385 81 8, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase 2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro apoptotic amino alcohol sphingosine to sphingosine 1 phosphate (S1P), the lipid mediator that is pro survival and critical for