MDV-3100 - CAS# 915087-33-1 238 1 Inhibitors of NEP have

1 Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and

265(5175):1093-5

(1997) J Biol Chem

Chemical Name: 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)thiazole

10 and 30 mg/kg

MDV-3100 - CAS# 915087-33-1 238 1 Inhibitors of NEP haveEnzalutamide, also known as MDV3100, CAS No. 915087 33 1, is an orally bioavailable, organic, non steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, selective androgen receptor modulator MDV3100 inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation