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removal of SNS-032 reactivates RNA polymerase II
Chemical Name: N-[(2S)-1-amino-3-(3
Formula: C129H230N36O29S
InChiKey: XLTFNNCXVBYBSX-UHFFFAOYSA-N
Smiles: N[C@@H](CN1C=C(F)C(=O)NC1=O)C(O)=O
NB-598 Hydrochloride alafenamide hemifumarate removal of SNS-032 reactivates RNANB 598 is a potent competitive inhibitor of squalene epoxidase (SE). NB 598 suppresses triglyceride biosynthesis through the farnesol pathway. NB 598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB 598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB 598 suppressed the basolateral secretion of apolipoprotein (apo) B.
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