1, 4:3, 6-Dianhydro-α-D-glucopyranose 2 cycl Izencitinib (TD-1473) inhibits cytokine-evoked STAT

Izencitinib (TD-1473) inhibits cytokine-evoked STAT phosphorylation in human peripheral blood mononuclear cells (PBMCs) and in a human colonic epithelial cell line (pIC50 ≥ 6

Oral administration of PF-1355 reduces plasma MPO activity

which have been known to be redox sensitive

Smiles: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=CC=C43)OC(=O)C3C=CC=CC=3)[C@@H]1CC[C@@H]2OC(=O)COC(=O)CCCC1C=CC(=CC=1)N(CCCl)CCCl

mainly through inhibition of c-MYC and upregulation of p21

1, 4:3, 6-Dianhydro-α-D-glucopyranose 2 cycl Izencitinib (TD-1473) inhibits cytokine-evoked STAT1,4: 3,6 Dianhydro D glucopyranose is a natural compound isolated from B. noctiflora leaves. Product information CAS Number: 4451 30 3 Molecular Weight: 144. 13 Formula: C6H8O4 Chemical Name: 2,5,8 trioxatricyclo[4. 2. 1. 0,]nonan 9 ol Smiles: OC1C2OCC3OC1OC23 InChiKey: XOTJGHCMZOLIPX UHFFFAOYSA N InChi: InChI=1S C6H8O4 c7 3 5 4 2(1 8 5)9 6(3)10 4 h2 7H,1H2 Technical Data Appearance: Solid Power Purity: 98% (or refer to the Certificate of Analysis)