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2015 Dec 9
LGK974 is a highly potent
CFTR Inhibitor 172
compared with bortezomib
targeting Smoothened (Smo) with an EC50 ~1 nM
TRX-818 - CAS# 1256037-58-7 039 2015 Dec 9TRX 818, also known as Foslinanib, CVM 1118, CAS No. 1256037 58 7, is an orally bioavailable agent with potential antineoplastic and anti vasculogenic mimicry (VM) activities. Although the exact multiple mechanisms of action through which this agent exerts its effects have yet to be fully elucidated, TRX 818, upon oral administration appears to induce cancer cell apoptosis and inhibits cancer cell proliferation. This agent also prevents tumor cell VM
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