CUDC-101 - HDAC/EGFR/HER2 Inhibitor. CAS# 1012054-59-9 60129 Smiles: O=C(NCC1(CCOCC1)C1=NC(=CS1)C1C=CC=CC=1)C1C=C(C=CC=1)C1N=C(ON=1)C(F)(F)F

Smiles: O=C(NCC1(CCOCC1)C1=NC(=CS1)C1C=CC=CC=1)C1C=C(C=CC=1)C1N=C(ON=1)C(F)(F)F

Mirogabalin (DS-5565) is a novel

and serves as an excellent chemical probe for investigating DOT1L and further development of DOT1L inhibitors for cancer therapy

425(6960):780-2

It inhibits recombinant human JAK1 (IC50 ~ 3

CUDC-101 - HDAC/EGFR/HER2 Inhibitor. CAS# 1012054-59-9 60129 Smiles: O=C(NCC1(CCOCC1)C1=NC(=CS1)C1C=CC=CC=1)C1C=C(C=CC=1)C1N=C(ON=1)C(F)(F)FCUDC 101, CAS No. 1012054 59 9, is a potent multi target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4. 4 nM, 2. 4 nM, and 15. 7 nM, respectively. It is specific for class I and class II HDACs, not for class III Sir type HDACs, and has > 50 fold selectivity against other protein kinases. CUDC 101 displays broad antiproliferative activity in many human cancer cell types with IC50 of 0. 04 0. 80 M, exhibiting a higher potency than erlotinib,