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The thrombopoietin (TPO) receptor agonists are novel treatments for patients with chronic ITP aimed at increasing platelet production through interactions with the TPO receptor on megakaryocytes
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989)
which is via inhibition of NF-κB and/or Sp1 transcriptional activity
Solubility: DMSO : 125 mg/mL (97
Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs
Pz-1 roxyatis-16-ene-3 14-dione The thrombopoietin (TPO) receptor agonistsPz 1 is a potent RET and VEGFR2 inhibitor with IC50s of less than 1 nM for both wild type kinases. Product information CAS Number: 1800505 64 9 Molecular Weight: 454. 52 Formula: C26H26N6O2 Chemical Name: N (5 tert butyl 1,2 oxazol 3 yl) 2 {4 [5 (1 methyl 1H pyrazol 4 yl) 1H 1,3 benzodiazol 1 yl]phenyl}acetamide Smiles: CN1C=C(C=N1)C1C=C2N=CN(C2=CC=1)C1C=CC(CC(=O)NC2C=C(ON=2)C(C)(C)C)=CC=1 InChiKey: NJLMIILZNLZZFW UHFFFAOYSA N InChi: InChI=1S