BI-3406 Size:10mg solid [Epub ahead of print] PubMed

[Epub ahead of print] PubMed PMID: 26317790

AR231453 can stimulate β-cell replication and improve islet graft function

InChi: InChI=1S/C16H16N2O/c1-12-6-2-3-7-13(12)10-18-15-9-5-4-8-14(15)17-16(18)11-19/h2-9

122 μM and 0

Formula: C14H14N3NaO5

BI-3406 Size:10mg solid [Epub ahead of print] PubMedBI 3406 is Potent & Selective SOS1:: KRAS Inhibitor (IC50=5 nM), which Opens a New Approach for Treating KRAS Driven Tumours. BI 3406 selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation. BI 3406 causes RAS GTP and pERK reduction and inhibits cell growth of KRAS mutated cell lines, carrying most of the typical KRAS mutations (i. e. G12D, G12V, G13D and others). BI 3406, when administered orally to tumour