GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 CAS Number: 66428-89-5

CAS Number: 66428-89-5

1138549-36-6

74(1):49-56

is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM

AG-221 was used at 1 µM in vitro and cellular assays

GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 CAS Number: 66428-89-5GNF 7, CAS No. 839706 07 9, is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF 7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. Product information CAS Number: 839706 07 9 Molecular Weight: 547. 53