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and dorsal root ganglion sensory neurons
is a potent FLT3/AXL inhibitor
an inhibitor of the glucosidases that convert protein N-linked high mannose carbohydrates to complex oligosaccharides
The long terminal repeat (LTR) of HIV-1 is the target of cellular transcription factors such as NF-κB
and is weak or inactive as a GABA receptor agonist
Cilomilast-d9 ide D and dorsal root ganglion sensoryCilomilast d9 (SB 207499 d9) is the deuterium labeled Cilomilast. Cilomilast (SB 207499) is a potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4), with IC50s of ~100 and 120 nM for LPDE4 and HPDE4, respectively. Cilomilast shows selectivity for PDE4 over PDE1, PDE2, PDE3 and PDE5 (IC50=74, 65, >100, and 83 M, respectively). Cilomilast has anti inflammatory and immunomodulatory effects and can be used for thr research of asthma
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