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CH 5132799
incorporates an E3 ligase ligand plus an alkyl C3 linker and terminal amine ready for conjugation to a target protein ligand
tumor cell proliferation and metastasis
CAS Number: 961-07-9
Crossing the blood brain barrier
CP-466722 Size:Solid 10 mg CH 5132799CP 466722 is an ATM inhibitor. CP466722 inhibited cellular ATM dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP466722. Interestingly, clonogenic survival assays showed that transient inhibition of ATM is sufficient to sensitize cells to IR and suggests that therapeutic radiosensitization
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