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PubMed Central PMCID: PMC4397880
Catrullo A
Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells
127(2):337-43
1021/cb400837t
WP1130 (Degrasyn) - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 856243-80-6 Catalog No.:M60206-2S PubMed Central PMCID: PMC4397880WP1130 (Degrasyn), CAS No. 856243 80 6, is a cell permeable, potent and selective inhibitor of the deubiquitinylating enzymes (DUBs). At 5 M it directly inhibits DUB activity of USP9x, USP5, USP14, UCH L1, and UCH37, but not UCH L3, resulting in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL 1 and p53. WP1130 suppresses Bcr Abl, JAK2 transducer (without affecting 20S proteasome) and activator of transcription
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