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Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives
also known as barbaloin
has improved pharmacokinetics
) also dose-dependently increases penile length in diabetic rabbits
InChi: InChI=1S/2C13H13N3O3
LCL161 Size:Solid 10 mg Synthesis and in vitro cytotoxicityLCL161 is a n orally bioavailable second mitochondrial derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic