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Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid 34 μM for BRD4 (1)

SKU: 44227914341

4.3
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Description

34 μM for BRD4 (1) and BRD4 (2)

27)23-7-9-28-10-8-23/h2-6

It can suppress proliferation

InChi: InChI=1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H

and has slight activity against HDAC8 (IC50 ~0

Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid 34 μM for BRD4 (1)Rapamycin, CAS No. 53123 88 9, is a potent and selective mTOR inhibitor. Rapamycin, in complex with the cytosolic protein FK binding protein 12 (FKBP12), inhibits mTOR Complex 1 (mTORC1) by binding to the FRB domain of mTor. Given the central roles mTor plays, Rapamycin showed diverse activities, including anti proliferative effects in cancer cells, immunosuppressive effect, lifespan extension in mice, improved cognition in the mouse model of autism

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