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18H-oxacyclotetradeca[3
Morimoto M
72 hours) dose-dependently inhibits HepG2 cell proliferation
24)/t17-/m0/s1
InChiKey: RIWWMGQFMUUYIY-ALLHVENQSA-M
EL-102 islignan 18H-oxacyclotetradeca[3EL102 is a inhibitor of HIF1 , Which can inhibit tubulin polymerisation and decreased microtubule stability. target: HIF1IC 5020 40 nM. in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI stained cells cultured for 24, 48 and 72 h, following treatment. EL102 induces apoptosis and causes G2 M arrest, preventing the cell from entering into mitosis. In vivo: CWR22 tumours were taken from
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