Ramelteon metabolite M-II 4010 PTGR2-IN-1 is a potent PTGR2

PTGR2-IN-1 is a potent PTGR2 inhibitor with an IC50 of ~0

) ameliorates indomethacin-induced enteropathy

4 weeks) dose dependently reduces the UACR compared to vehicle in uni-nephrectomised male Sprague Dawley rats administered aldosterone and fed a high-salt diet

but not in HCT116

AH 23848 inhibited TXA2-induced platelet aggregation and antagonized the contraction of human bronchial smooth muscle induced by the TP agonist U-46619 with pA2 of 8

Ramelteon metabolite M-II 4010 PTGR2-IN-1 is a potent PTGR2Ramelteon metabolite M II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist. Product information CAS Number: 896736 21 3 Molecular Weight: 275. 34 Formula: C16H21NO3 Chemical Name: 2 hydroxy N {2 [(8S) 1H,2H,6H,7H,8H indeno[5,4 b]furan 8 yl]ethyl}propanamide Smiles: CC(O)C(=O)NCC[C@@H]1CCC2=CC=C3OCCC3=C21 InChiKey: FGFNIJYHXMJYJN KFJBMODSSA N