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Arthritis Rheumatol
In sensitized mice
11 μM (LOX-IMVI cells)
obesity and metabolic syndrome
Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells
A 943931 dihydrochloride l O-β-D-glucopyranoside Arthritis RheumatolA 943931, is an H4R (one of histamine receptor subtypes) antagonist with high affinities to H4Rs of human (Ki = 5 nM), rat (Ki = 4 nM) and mouse (Kb = 6 nM) . H4R is one of 4 known G protein coupled receptors (H1, H2, H3 and H4 receptors) of histamine for histamine to mediate its physiological functions . HMC 1 cells incubated with A 943931 at a concentration of 300 nM for 20 min inhibited the increase in ALDH2 activity induced by H4R . In microglia,
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