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SGK3-PROTAC1 suppresses proliferation of ZR-75-1 and CAMA-1 cancer cell lines treated with a PI3K inhibitor more effectively than could be achieved by a conventional SGK isoform inhibitor
is a new TGF-beta type I receptor inhibitor with a much improved pharmacokinetic profile compared with SB431542
2018 Jan 4
Smiles: CC(C)C1=CC(=NC(N)=N1)C1=CC=C(F)C2=CC=CC=C21
Steinberg SM
JWG-071 hibitor SGK3-PROTAC1 suppresses proliferation of ZR-75-1JWG 071 is the first reported kinase selective chemical probe for ERK5. JWG 071 improves ERK5 activity and BRD4 selectivity. JWG 071 will be a much needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology. Product information CAS Number: 2250323 50 1 Molecular Weight: 612. 76 Formula: C34H44N8O3 Chemical Name: 2 (butan 2 yl) 5 ({2 methoxy 4 [4 (4 methylpiperazin 1 yl)piperidine 1 carbonyl]phenyl}amino) 9 methyl 2, 4, 6, 9 tetraazatricyclo[9.
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