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Ischemin is a good chemical probe to modulate acetylation-mediated interactions in gene transcription and a new approach to therapeutic interventions of human disorders such as myocardial ischemia
56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18
PubMed PMID: 25486573
Falschlunger J
Epub 2017 Dec 28
Danusertib (PHA-739358) Catalog No.:M7725-10 Ischemin is a good chemicalDanusertib, also known as PHA 739358, is a small molecule 3 aminopyrazole derivative with potential antineoplastic activity. Aurora kinase inhibitor PHA 739358 binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine threonine kinases, are important
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