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GSK2981278
Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases
Chemical Name: 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1
which is an angiotensin converting enzyme (ACE) inhibitor
Treatment of P
CpdA Size:Contact [email protected] for quotation GSK2981278CpdA is a non steroidal selective glucocorticoid receptor modulator. It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus. It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF B and subsequent cytokines through transrepression. Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone that were either higher (4 fold, IC50 =
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